Two cases of idiopathic multicentric Castleman disease with nephrotic syndrome treated with tocilizumab
نویسندگان
چکیده
منابع مشابه
Sustained remission of Multicentric Castleman Disease in children treated with tocilizumab
Background Multicentric Castleman Disease (MCD) is an idiopathic lymphoproliferative disorder, exceptionally reported in children, probably due to an increase of interleukin 6 secretion. MCD is characterized by systemic lymphadenopathy and constitutional inflammatory symptoms including severe growth retardation. Previous studies in adult showed that anti-interleukin 6 receptor antibody alleviat...
متن کاملSustained remission of multicentric Castleman disease in children treated with tocilizumab, an anti-interleukin-6 receptor antibody.
Multicentric Castleman Disease (MCD) is an idiopathic lymphoproliferative disorder, reported exceptionally in children and generally believed to be an autoinflammatory disease resulting in an increase of interleukin-6 secretion. Previous studies in adult patients suggested a beneficial role of the anti-interleukin-6 receptor antibody tocilizumab on the clinical and biologic disease manifestatio...
متن کاملRelationship of Renal Cortical Echogenicity in Renal Ultrasonography with Course of Disease in Children with Idiopathic Nephrotic Syndrome
Background It is important to find a predictor for the course of Idiopathic Nephrotic Syndrome for better planning of treatment. Renal cortical echogenicity in ultrasonography has been postulated as a marker for the course of renal disease. The present study aimed at evaluating the relationship between renal cortical echogenicity and the course...
متن کاملtwo cases of castleman disease with nonspecific clinical presentations
castleman disease (cd) is a rare, lymphoproliferative disorder of uncertain etiology. we are reporting on two cases of castleman disease. both patients were female. this disease can be found wherever lymph nodes are present. we have reported two unusual cases of castleman disease. a 29- year old woman was referred for evaluation because of a cervical lymph node, weight loss and night sweats. th...
متن کاملShort-term efficacy of the IL6 receptor antibody tocilizumab in patients with HIV-associated multicentric Castleman disease: report of two cases
Multicentric Castleman disease (MCD) is a lymphoproliferative disorder caused by human herpesvirus 8 (HHV8) infection HIV associated MCD (HIV-MCD) presents with various clinical symptoms. Many HIV-negative MCD patients are often treated with anti-human interleukin-6 (IL6) receptor monoclonal antibodies (tocilizumab), and successful results have been reported. IL-6 plays an important role in the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: CEN Case Reports
سال: 2020
ISSN: 2192-4449
DOI: 10.1007/s13730-020-00511-8